The Brutal Reality For Most Men Today (& how to fix it) - Dr K HealthyGamer - #1151

“And then we're starting to see some really scary things around GLP-1s. So, they're amazing medicines because if you have, if you have like, if you're overweight and you have like cardiac risk factors, endocrinological risk factors like type 2 diabetes and stuff like that, these medications are amazing at all this kind of stuff.”

“Pornography gets worse. Yes. Video games? I haven't seen any data about that. Yeah. So, and there's a lot of really interesting signaling around GLP that we can get into, but this is exactly kind of what I mean is it's sort of a miracle drug. And our society has been filled with miracle innovations that actually cause silent damage around the edges.”

“isn't using control themselves, but is, is artificially supplementing their control by using GLPs? Your suggestion here is that people use CBT. There's an intervention that gives somebody an additional amount of control over their weight and how much they eat.”

“kind of addiction to the control that they have. Are you suggesting that GLPs allow people to shortcut or people who wouldn't have typically that access to willpower, that these people would, uh, and they they're able to, um, the mechanism still holds, even though the way that they've arrived at the mechanism isn't, isn't the same mechanism is the same.”

“really high willpower. So the reason I think GLPs are causing lots of problems with body dysmorphia is because now I don't need a high willpower because I'm reducing my cravings. So, so they basically, allow people who have less control of themselves to achieve more dysmorphic goals.”

“So even people who are more overweight see greater reductions in alcohol use with GLP use compared to people who are normal weight. So if you have a normal weight and you start a GLP, your reduction in alcohol consumption is lower.”

“Well, that depends how messed up is your heart. And in the same way, the majority of GLP benefits are for people who are very unhealthy, right? And there's a lot of data that supports that. But then the second thing that I, this is like my personal thing.”

“are empty, you're not going to feel any of that. And so people aren't falling in love anymore because technology is draining our dopamine. Are you worried about GLPs impacting dopamine for people falling in love or cravings, I guess? Yeah. So they do blunt cravings. This is where things get like really neuroscientifically like.”

“GLPs do is they cap the amount of dopaminergic response that you can get. That's part of the reason that they're kind of like good. So if you look at studies of people who use alcohol on GLPs, their desire for the first drink is the same.”

“beer is blunted. And so that's really where GLPs work. Okay. So going back to someone doing all three of those things every day. So anhedonia is number one. So the inability to experience pleasure. If you talk to these people, life will feel boring, which is why they want to pass the time, right?”

“right so you're right it's it's all of the outcomes it is it is a deconditioning of people whole scale but glps i would guess for people starting under a bmi of 30 would probably”

“pieces of advice that i give to people this is family friends patients whatever when they start a glp i mean usually i don't prescribe glps so somebody else should be doing this but if i have a patient who's on it i try to tell them remember to eat so so they just don't feel like eating and”

“a lot of data that glps are like really good you know and i'm not saying that they're not good when you look at those indicators but there are these hidden costs like maybe we'll see micronutrient”

“that the same thing that happened with opioids is what's happening with GLPs so were they designed for morbid obesity or did the companies that develop them understand very clearly that this is a medicine that will make someone not want to eat?”

“but this is like a weight loss drug, right? That people, but it just had side effects that were completely unacceptable. Oh. And so GLPs, like there's a, there's a very real chance that someone somewhere, and I'm not, I don't think like pharma, like pharma is evil and bad and stuff like that. I think a lot of pharmacologic, I mean, no one's complaining about acetaminophen.”

“And so everyone wants to be thin and everyone wants to be beautiful. And like social media is a big part of that. Yep. So then along comes a medication, which is amazing, because this medication makes it so that you don't want to eat. So this is what's really scary about society.”

“And what scares me about semaglutide is up until now, if you wanted to be healthy, if you wanted to have, if you wanted to lose weight, if you wanted to get fit, it required you to put in a certain amount of effort.”

“can really control, which is yourself. That's the only thing you can control. And here we are having a lot of people offering us solutions that semaglutide is a great example, remove the need to work on yourself.”

“They're not the same thing. Tirzepatide, semaglutide, they're not the same. They all have different penetrations to the CNS. Okay. So where all of these GLPs go is actually different. So if you look at studies on reductions in alcohol cravings and alcohol addiction, they're not the same for all GLPs because they have different CNS penetration.”

Also filed under GLP-1 Agonists

“Yep. Too. I was living in a five-person house in university. I used to play Borderlands and you could play Borderlands Co-op locally, which was sick. Because it's you and another person doing the same thing, talking shit to each other, but like working on a team, but complaining about stuff.”

“used to play Borderlands and you'd hang out with your friends. Like all that kind of stuff is shaping your mind, right? So how lonely do you feel? And if your mind feels less lonely, getting it to do things is like way easier.”

“If anything, body, body dysmorphia is on the rise, right? And we have some of these things like Ozempic and semaglutide and stuff like that. Really scary. A lot of people don't realize. I'm going off, off. Oh, dude. I'm fucking loving this. You're cooking. Keep going.”

Also filed under Semaglutide

“I think we sort of feel it. We see evidence of it in mental health. But we were talking about Ozempic. So, basically, what happened is up until now, you've had to work to get something, right? And along comes semaglutide and these GLP-1 agonists.”

Also filed under Semaglutide, GLP-1 Agonists

“Haldol, haloperidol is an amazing medication. SSRIs are amazing medications. I'm not like anti-pharma, but I really wonder when I see something that has such rapid adoption that does so many things.”

“So this is something that when I, the first book that I wrote is How to Raise a Healthy Gamer. And I taught this to parents because parents who are struggling to teach their kids or parents who are struggling to get their kids off of video games need to understand that this first thing is it's not a game.”

“Everyone's like, yeah, OxyContin has long half-life. People aren't going to get addicted to it. They knew people were going to get addicted. Well, the only way that your theory isn't true is if the most well-funded pharma research companies in the world didn't foresee what would potentially be the biggest drug market on the planet.”

“So now we're moving away from those addictive ones. Here's a really fascinating thing: everyone talks about GLPs like they're the same thing. They're not the same thing. Tirzepatide, semaglutide, they're not the same. They all have different penetrations to the CNS.”

Also filed under GLP-1 Agonists

“what is the visibility? Okay. So example of low lethality, low visibility is I took a bottle full of Tylenol. Bottle had two pills in it.”

“hits you fast, goes away fast. Diazepam, which is valium, hits you fast, but stays for a long time. So now we're moving away from those addictive ones. Here's a really fascinating thing: everyone talks about GLPs like they're the same thing.”

“anatomical parts. There's also valves that become really important. And this is where you mentioned nitrous oxide. So, if we look at sildenafil, which is Viagra, it's a nitrous oxide, it increases the levels of nitrous oxide, basically. It's a phosphodiesterase V inhibitor.”