#392 - Genetic testing: when it's valuable, how to choose the right test, and what to do with the results

“and carries one of these loss-of-function mutations, they can instead be prescribed a different drug that does not require CYP2C19. A very different example is HLA-B58 and the drug commonly used to treat uric acid, called allopurinol.”

“There are emerging therapeutic strategies, such as obicetrapib , which we've also covered on this podcast, being studied that specifically show promise in ApoE4 carriers”

“make this enzyme completely nonfunctional, meaning their body can't convert Plavix into a usable compound. For someone who needs reliable platelet inhibition after a stent or another vascular event and carries one of these loss-of-function mutations, they can instead be prescribed a different drug that does not require CYP2C19.”