#413 ‒ The neuroscience of emotion: challenging conventional theories of emotion, how the brain predicts and constructs our experiences, and gaining greater control over how we feel | Lisa Feldman Barrett, Ph.D.

“And we could, without getting into the nuances of it, there was a huge debate as to whether anyone should ever receive Zetia and monotherapy. And it was viewed as not an evidence-based approach because it didn't have the hard outcome trial that said, if you give Zetia in monotherapy, you will save lives.”

“And I think there's still a lot of pushback to that approach. And I would argue that what you've pointed out is another example of that, which is to say, on average, giving Zetia as monotherapy probably doesn't save lives. But if you could target the people who are super responders.”

“synthetic thyroid, you can arrest the progress. These aren't clinical trials. They're not large and it doesn't work for everybody. So I took, I went back to him and I went, look at these studies.”

“And it might not work for me forever either. But the thing is, so now I'm on a low dose of levothyroxin and I'll be on that low dose for the rest of my life. But that's better, I think, to still have a thyroid and be on this low dose than to be on a much larger dose and not have one for the rest of my life.”

“hmm, was it called The Principles? No, what was it called? We're going to find it, we're going to put it in the show notes. It'll come to me. Yep. This book is like, this is a, this is a masterpiece. This book is a masterpiece because they basically, I think they go over a fly, um, a mouse and a primate, maybe, no, maybe it's a fly, a worm.”

“I don't know. Principles of neural design. It's called the principles of neural design. I don't know. I certainly haven't ever treated that as evidence before.”