the DO-HEALTH study21:06
“the first study. This was referred to as the do health study. And it's, I think it's a reasonable use case example”
The Peter Attia Drive
#386 - Aging clocks—what they measure, how they work, and their clinical and real-world relevance
7 months ago
Products mentioned (4)
20:24
“It was a very simple intervention. They used omega-3 supplementation, vitamin D supplementation, and exercise. And then they asked the question, will those simple interventions, and I'll talk about them in a little bit more detail, move the needle on the four most common epigenetic aging clocks in a randomized fashion?”
Discussed
23:06
“one gram a day that contained 330 milligrams of EPA, 660 milligrams of DHA. And this was from marine algae”
Our IdentificationDescribed, not named. We believe this refers to Omega-3.
Discussed
29:12
“balance, you know, the most consistent finding was that something about omega-3 supplementation moved the needle in at least three of the four clocks. So the only clock that it didn't move the needle in was the first gen grim age.”
Discussed
48:08
“this case, it was omega-3 supplementation that appeared to slightly slow several epigenetic clocks over three years. The second study, the Dunedin PAC-NI paper, showed that scientists could build new types of aging clocks, in this case, using structural brain imaging, that appear to capture meaningful patterns related to cognitive decline, frailty, and even overall mortality.”
Discussed
20:24
“It was a very simple intervention. They used omega-3 supplementation, vitamin D supplementation, and exercise. And then they asked the question, will those simple interventions, and I'll talk about them in a little bit more detail, move the needle on the four most common epigenetic aging clocks in a randomized fashion?”
Discussed
21:59
“they tested these three interventions that I talked about. So giving vitamin D, giving EPA, DHA, and assigning exercise. They tested them individually and in combination. So each individual is then randomized to one of eight groups for the duration of the study, which is a three-year duration study.”
Discussed
23:00
“2000 IU of vitamin D, a relatively modest amount of EPA and DHA. So one gram a day that contained 330 milligrams of EPA, 660 milligrams of DHA. And this was from marine algae. And then adherence for both the vitamin D and omega-3 levels was assessed by changes in serum level.”
Discussed
29:54
“people with really, really low omega-3 intake, they're going to be able to do that. And again, you don't need much to move the needle. The vitamin D supplementation, as I said, didn't really impact the clocks at all. But again, given the dosage, I don't think that was surprising. 30% of these participants had a baseline level below 20 nanograms per deciliter. So it's possible that”
Discussed
21:59
“they tested these three interventions that I talked about. So giving vitamin D, giving EPA, DHA, and assigning exercise. They tested them individually and in combination. So each individual is then randomized to one of eight groups for the duration of the study, which is a three-year duration study.”
Discussed
23:00
“2000 IU of vitamin D, a relatively modest amount of EPA and DHA. So one gram a day that contained 330 milligrams of EPA, 660 milligrams of DHA. And this was from marine algae. And then adherence for both the vitamin D and omega-3 levels was assessed by changes in serum level.”
Discussed
21:59
“they tested these three interventions that I talked about. So giving vitamin D, giving EPA, DHA, and assigning exercise. They tested them individually and in combination. So each individual is then randomized to one of eight groups for the duration of the study, which is a three-year duration study.”
Discussed
23:00
“2000 IU of vitamin D, a relatively modest amount of EPA and DHA. So one gram a day that contained 330 milligrams of EPA, 660 milligrams of DHA. And this was from marine algae. And then adherence for both the vitamin D and omega-3 levels was assessed by changes in serum level.”
Discussed
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Studies cited in this episode (5)
As referenced on air, with the quote and the moment. Reported, not evaluated.
the CALERIE trial34:31
“There's a very famous study called the CALERIE trial. This was run out of Pennington many years ago. Eric Robison, who's a previous guest on the podcast actually was the PI for that. But the data set from CALERIE has been used multiple times. This was a CALERIE restriction study and it showed that, so the CALERIE restriction showed a reduction in in pace of aging using the Dunedin PACE clock”
the Dunedin Multidisciplinary Health and Development Study36:01
“The Dunedin Multidisciplinary Health and Development Study, and I just want to kind of give you the background on where this cohort comes from, has been a very long running longitudinal cohort, as I mentioned, based in New Zealand”
the DO Health trial47:56
“The first study, the DO Health trial, shows that aging clocks can detect small biological changes in response to an intervention. And in this case, it was omega-3 supplementation that appeared to slightly slow several epigenetic clocks over three years.”
the Dunedin PAC-NI paper48:14
“The second study, the Dunedin PAC-NI paper, showed that scientists could build new types of aging clocks, in this case, using structural brain imaging, that appear to capture meaningful patterns related to cognitive decline, frailty, and even overall mortality.”