Atorvastatin

“of a sudden it says, oh, maybe just like lipitor for cardiovascular disease or hypertension for cardiovascular disease, maybe I have a marker.”

“So, as you very well know, every medicine, every drug, aspirin, lipitor, you know, Prozac, works by binding to something.”

“And so, the key has to be a little bit of a wriggle of a key that goes in, but basically it's all aspirin is a key. We know the lock, lipitor is a key, we know the lock, Prozac is a key, we know the lock, and so forth. All right, so in the past, we had two ways of looking for keys.”

“I was just about to say, will there be a drug? Just as I can give you lipitor today long before you have a heart attack, and I can give it to you with an ACE inhibitor if your blood pressure is high, these two molecules will prevent you from having a heart attack.”

“chemo prevention is going to be as simple. So remember, lipitor blocks decreases your LDL levels and Losartan or whatever ACE inhibitor or ARB inhibits your capacity to have high blood pressure by acting on your kidneys, hormonal system.”

“and we have treatments for all of them. You can take aspirin lipitor and PCSK9. You can take like 17 drugs now. That's right. So if you don't smoke, if you take whatever drugs are necessary to stay insulin sensitive, if you obliterate your”

“And there have been great examples of that. Think Atorvastatin and Rosuvastatin in a Mevacor, Zocor world. And those have been enormous commercial successes, and there's a strong bias throughout the drug development infrastructure to do those kinds of things because they're relatively low risk and there's not so much uncertainty.”

“it's- All right. So first this was Pfizer combining this with Atorvastatin in a clinical trial. Okay. Go back from that a decade into the discovery of yet another mechanism, because you've already alluded to this, which is lowering LDL is the goal, but there are many paths to get there.”

“Again, all on maximal statins, majority on high-intensity statins, like 70% were on 20 or 40 of Rosuvastatin or 40 or 80 of Atorvastatin. They're all very well treated. And we got roughly around a 35% LDL-lowering benefit. And then adjusting for placebo, a little less than that. But it was around that percent change at 12 weeks and then it continued for 52 weeks.”

“I don't like 80 milligrams of Atorvastatin in particular. I don't like 40 milligrams of Rosuvastatin. Have you seen Tom Dayspring put out a beautiful figure? It's one of your classic Tom figures that he pulled out of all the literature, and it shows the dose response of every statin.”

“pravastatin, atorvastatin, rosuvastatin. The entire class of drugs that by any reasonable estimate has prevented millions of cardiovascular events and millions of premature deaths.”

“It certainly can get into the brain. maybe a little less slowly than lipitor, lipophilic statin, can, but if you're in a steady state, they're all in. They all have the ability to reduce cholesterol synthesis in the brain.”