Mentioned 15 times on 2 shows.
“I'm surprised that we don't also see that post ovulation because you also have a very sharp decline in estradiol post ovulation. They kind of have two. They're sharp. They're not as sharp at the end of ovulation and then not as sharp at the end of the luteal phase. Did they see anything mid-cycle?”
“In other words, we ended up having to use estradiol and progesterone, as you do in perimenopausal women, but less than you would normally have treated someone. In other words, we couldn't take her to full therapeutic dose. Is that common in menopausal women?”
“But I think enough that they'll understand, because I think we have to understand serotonin if we're going to talk about the endocrine system and how estradiol and serotonin factor in this life. So I want to make sure we get everybody up to a certain level of understanding, and I think the drugs help us do that. Sure. Well, on a foundational level, psychotropics”
“off of estradiol. And similarly, for both sexes, that men who needed testosterone, weren't getting it, were being told it wasn't safe, similarly had an erosion of their function across multiple domains.”
“within that framework. In other words, is there actual estradiol in a synapse or is it removed from that given its size and it's regulating it? It's regulating upstream of the actual synaptic contents between, you know, where the actual neurotransmitters live.”
“of psychopathology or emotional variability in response to change in estradiol levels, it's more the actual change and fluctuations and oscillations of those levels themselves.”
“Absolutely. Can you say anything about this in men? Because, again, I think this is counterintuitive, but I don't think men are particularly less susceptible to this, both testosterone and estradiol. Yeah, well, let's start. Let me just say men get their estradiol from testosterone, from the aromatization of testosterone.”
“of testosterone. So, testosterone is a pro-drug for estradiol, as well as, of course, being a primary drug for all the obvious reasons. But as a primary hormone, testosterone modulates, there's a lot of system redundancy.”
“that might be worth your reiterating. Yeah. I think what's always misleading when you look at a laboratory report is the number for estradiol is so much bigger than the number for testosterone in women. Right. But that's because testosterone is reported in picograms per mil per deciliter.”
“Testosterone is reported in nanograms per deciliter. Estradiol is reported in picograms per deciliter. So you have to normalize those because they're off by a factor of a thousand. And when you do that, you realize that a woman's testosterone level is about 10 times higher than her estradiol level, although it's about one-tenth the level of a man.”
“And with estradiol levels and progesterone at their peaks, these women are, you know, women in general at the end of pregnancy are primed to be in wonderful moods.”
“change can occur in that critical window. And I find that of interest because, of course, estradiol creates a lot of neuroplasticity because it acts through BDNF and NMD and glutamate.”
“optimal estradiol levels, for example. And giving, administering a psychedelic medication can also alter neuroplasticity, is intended really to alter neuroplasticity in the studies of psychedelics for the most part.”
“Mm-hmm. This is where we're going to start. Now the Dutch test, I think, is good for looking at metabolites or variations of your estradiol Mm-hmm. and your progesterone and what they're actually doing, right? Yeah. It's a good follow through to see exactly where— Yeah.”
“Creation made this stuff up. I was fascinated when I found out it came from yams too. Yeah, right. So, okay, estradiol, your body's... There are three or four kinds of estrogen, but this is the main one to restore to your body.”