Mentioned 9 times on 2 shows. Most recently heard 17/08/2026.
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“Lamotrigine can be very effective about treating depression. People think of bipolar drugs as treating the elevated moods, but lithium and lamotrigine, for example, can be very effective at treating depression with monotherapy for many patients.”
“I think it changes sodium channels. Okay. And do we know why lithium works? I don't believe so. Okay. So lithium monotherapy or Lamictalin monotherapy is not just given to manage the mania, but you're saying it can also improve the depression.”
“in combination therapies with antidepressants and mood stabilizers and let's say lithium, which is a so-called augmentation strategy. But this was not bipolar. Not bipolar. Not depression.”
“that's separating out urea and uric acid. We're adding lithium to the uric acid. We're injecting this into guinea pigs. This is getting pretty wild and pretty weird, but this is medicine. And from time to time, this is medicine and science.”
“And by good scientists, I mean that he did control experiments. Here he was injecting lithium urate into animals and seeing an effect, but he knew that that solution of lithium urate contained not just the uric acid, but it also contained lithium.”
“on these guinea pigs. And indeed, that was the case. When he did the proper control experiment and injected only lithium solution into these guinea pigs, they calmed down. From there, he, in sort of 1940s style medicine,”
“if it has any side effects at all, there is the possibility for better treatments. And only by understanding how lithium works at the cellular level, at the neural circuit level, et cetera, do we really stand to find those new discoveries. Lithium seems to be able to suppress inflammation and importantly, it can suppress inflammation in neural tissues and within the brain in particular.”
“be present in bipolar disorder and the different forms of bipolar disorder and some of the major treatments for bipolar disorder, in particular lithium and its underlying mechanisms. I do hope you found it beneficial both for yourself and for others. I just want to remind people that bipolar disorder is an extremely serious condition. If you suspect that you have bipolar disorder or you”
“Now, there are some interesting examples. So Tylenol is an exception. Believe it or not, we don't actually know how Tylenol works. We don't know how lithium works. You know, we did a newsletter on this somewhat recently talking about lithium for potential cognitive benefits. We don't actually know how it works. There's some speculation, but we don't know.”