Mentioned 6 times on 1 show. Most recently heard 17/08/2026.
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“And that's how it works for that drug. Now, there are also probably familiar to many of the audience a newer class called SNRIs, serotonin and norepinephrine reuptake inhibitors, and that gives a certain balance because raising serotonin can decrease dopamine.”
“So when you think about then the differences between a drug that gets formally labeled an SSRI versus a drug that gets formally labeled an SNRI, it's really just a continuum. Because it's basically saying like, I mean, I'm being a little bit cheeky, but if on a”
“and a four out of 10 on norepinephrine, at some point we just say, oh, well, we're going to start classifying you as an SNRI. That's true. I think it's underappreciated. You know, there are certain more pure SSRIs. So it sounds like Prozac was a very pure SSRI.”
“So when would an SNRI, which, again, you always think the newer the drug, the better it is, but when would you turn to an SSRI over an SNRI?”
“SNRIs stabilize mood? Well, irritability is such a huge category. And a lot of people with depression have a lot of irritability.”
“No. No. You were all SSRI or SNRI? Yeah. Okay. Yeah. Or bupropion. Okay. Which is Welbutrin for the listener. So each of those therapies in monotherapy had not been successful. And then even when you layered on presumably not a bipolar dose of lithium, but...”