Mentioned 13 times on 2 shows. Most recently heard 19/10/2026.
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“I was just about to say, will there be a drug? Just as I can give you Lipitor today, long before you have a heart attack, and I can give it to you with an ACE inhibitor if your blood pressure is high. These two molecules will prevent you from having a heart attack.”
“There are other hypertensives that we use sometimes, but those are two mainstays. Which is so interesting because, I mean, we just don't use those outside of pregnancy at all because they're not that good. So does that mean we do not know or we do know that ACE inhibitors or ARBs, which would be first line in someone who's not pregnant, do we know for sure that those are not safe in pregnancy?”
“But here, if you overshoot this, you can cause some damage. The ARBs are right there on par with the ACE inhibitors. In fact, we did an internal white paper on this very recently. The consensus view is that basically across the board, the ARBs are probably slightly better drugs than the ACE inhibitors.”
“slightly better, than the ACE inhibitor. The ACE inhibitors have been around longer. And so, one of the things that you have is you have more of them and they're cheaper. So, a lot of times people don't necessarily have a choice in them because their insurance company is going to pay for an ACE inhibitor. They're not going to pay for an ARB.”
“And I wouldn't consider myself at all an expert in the treatment of hypertension, but we typically do not like to rely on those as first-line agents and instead rely on those as add-on agents if we've maxed out an ACE inhibitor or an ARB and we still need more reduction.”
“So, that's something you want to keep in the back of your mind. It used to be, I think, the dogma that anybody with diabetes should be on an ACE inhibitor over an ARB if you're going down that path. I would say when we looked at these data, which we did for our internal white paper, we didn't see a strong enough case for that.”
“enough case for that. I thought the data were inconsistent here. So, I think I would say this: the textbook answer is for type 2 diabetes and chronic kidney disease, ACE inhibitors might offer some benefit. But I think that both of these are probably reasonable.”
“And race might also play a role here. It would appear that in African-Americans, thiazide diuretics or calcium channel blockers might actually be more effective than ACE inhibitors or ARBs or even beta blockers when it comes to reducing cardiovascular events.”
“Now ACE had previously been discovered, but the identification of a potent ACE inhibitor caught the attention of chemists at Squibb. The venom peptides themselves were not viable drugs.”
“from the Gerarica venom and used it as their structural lead and designed a small, orally active molecule that inhibited ACE, in the same way that venom peptide did. This is conventionally remembered as one of the earliest examples of rational, mechanism-based drug design.”
“They called the molecule captopril, and it was approved by the FDA in 1981 as the first oral ACE inhibitor in clinical use. And captopril begat enalapril, lisinopril, ramipril, and the rest of the ACE inhibitor class, and conceptually began the angiotensin regime. They were the main receptor blockers, losartan, valsartan, and so on.”
“from a jellyfish. Statins come from a fungus growing on rice. The ACE inhibitor class came from a snake whose venom kills by dropping blood pressure. PCR, and by extension, essentially all modern molecular biology, came from a microbe in a Yellowstone hot spring.”
“So he had a brittle he was a brittle hypertensive. He was on a beta blocker, what's called a calcium channel blocker and something called an ACE inhibitor. And they could not get his blood pressure down. It was life threateningly high. And this had gone on for years.”