Mentioned 8 times on 3 shows. Most recently heard 07/08/2026.
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“Right. Interesting. And then DHT inhibitors. Exactly. Also help. That'd be Dutasteride people can take orally. The problem with that is my friend had severe depression when he took that. Yeah. It really fucked him up, and he didn't realize, because he didn't understand that that was the, he was like, what is wrong with me?”
“a class of drugs called five alpha reductase inhibitors. The most common of these is finasteride, but there's another one called dutasteride, and how they impact prostate cancer screening. So the use of finasteride has exploded in recent years, largely driven by men using it to prevent or treat hair loss.”
“Okay. So. No, I certainly don't want to leave a podcast saying, get on Finasteride or Dutasteride, or else you're screwed. Like, there's an ROI calculation to be made similar to any sort of hormonal therapy that is not to be minimized. There are side effect profiles with these drugs, just as there is with any drugs.”
“is very significant and uh shockingly Dutasteride is a similar side effect profile to Finasteride even in studies comparing them where you have near full inhibition of systemic DHT versus only 60 to 70 percent via Finasteride which only inhibits two of the three isoenzymes in the scalp so it's like it's not there's a side effect profile it's just overblown by media but it's not zero”
“That seems like a legit pathway for some men that are like a little bit skittish about potential side effects with the oral um drugs as well, because like the Finasteride and do what is the other one Dutasteride um you know you mentioned the the erection but like is there are there any other serious side effects with those”
“like post Dutasteride or post Finasteride syndrome. Interesting you'll never have you you'll never hear about post Dutasteride syndrome though yeah even though it's a way more potent drug because it's largely a media driven construction it's not to say it's not real there's definitely side effects from”
“like the mild Ketoconazole which probably is not going to be sufficient but like over the counter pretty benign helpful good shampoo regardless that's why I use it but Finasteride or Dutasteride or topical antiandrogen probably going to be necessary for most people.”
“I take enough to put me at like 800 and like my free T is like the high normal. I think that the Dutasteride like probably whatever like excitotoxic toxicity or cardiotoxicity that I might otherwise be like net netting over into like an area I wouldn't want I would anticipate and speculate that the DHT reduction is probably inhibiting that whatever detriment might be there”