Mentioned 4 times on 2 shows. Most recently heard 14/09/2026.
Every quote is verbatim and timestamped, and checked before it appears. Sponsor reads are left out. How we check
“Don't you think it'll just be used off-label for that reason anyway? Well, we can unfortunately. You have nothing to do with that, but I'm just saying, like, look, people were using PCSK9 inhibitors off-label for LP-little A reduction the moment it became clear that it was lowering L P little A 20 to 30 percent.”
“Patients who don't progress all the way to type 2 diabetes, we do see an increase in insulin resistance. What do you think is explaining that? Well, first of all, it looks like all LDL-lowering drugs, even PCSK9s, have a little bit of a diabetes signal, except for Obicetrapib. It's just the opposite. Yeah. It is about LDL.”
“But certainly PCSK9 inhibitors genetically have that. So what do you think is the mechanism for that? I honestly don't know. I saw this recent data, which I think you talked about, where the change in the type of bile acids that you see could be a mechanism.”
“But that was a long time ago. Let's see, CoQ10, of course, because I'm actually on a statin. I might switch to a PCSK9 inhibitor because it's more effective, but my family is very high class. I'm on Repatha. Great. Yeah. You like it? I've actually stopped taking Repatha because I want to see if it's causing some brain fog.”