Rapamycin

“the DRTRCR framework. Why I stopped taking metformin for longevity and my shifting position on rapamycin. Whole body MRI and liquid biopsies for cancer screening, including why I think whole body MRI data quality has actually gotten worse”

“Haven't seen a lot of new data on that. Well, there was that study somewhat recently suggesting that rapamycin impaired, I don't know if it was impairing MPS or some other metric of physical performance or something.”

“And then we can test the biology. And do you think that just intermittent dosing of Everolimus or serolimus gets that? Maybe. Again, it's hard to tell in healthy people because, you know, in cancer, when you study mTOR inhibitors, the cancers have a highly upregulated pathway, and it's easy to see the biology.”

“There are hacks left, right, and center, and some of them have great merit. We talk about them in the book. You know, what's the future of would rapamycin be something that's in a brain healthy program? What about metformin? What about red light therapy? What about hyperbarics?”

“This is such an important part of the longevity playbook, and it's not sexy, right? It's not like taking rapamycin or taking some little drug that's going to whack your senescent cells or doing anything like that. I mean, this is just bread and butter primary care medicine, but it's so needle-moving.”

“Then there's drugs, which some of which may work. So that's metformin, rapamycin, some senolytics, and probably GLP1, receptor agonists would fall into that bucket. And then there's supplements, which is the Wild West.”