NMN

“NMN. Yes. NMN. Okay. So NMN. I think I would absolutely agree with you. I think Dr. David Sinclair would agree with you too. Like increasing our body's ability to make it naturally rather than just taking it in.”

“And it's been good to me. I also take that with NMN, which is an NAD supplement. It's a precursor. We studied both in my lab. And we just resubmitted a paper.”

“We'll see what they say. What was the controversy? Because I know since the last time we spoke, there's been some furore around resveratrol, some more furor around NAD, maybe NMN as well. Yeah. Can you explain what happened? Yeah, sure. These are all typhoons in a teacup or whatever it is.”

“Unless you want to complain about atomic theory, you know, we're done here. Okay. And what happened with NAD, NMN? So, yeah, let's bring everyone up to spear on what NAD is. So CERT1 also can be activated by giving it fuel, which is NAD.”

“Okay, I can give you examples. Shelly Basin, you could look up in PubMed, he's got a couple of really good papers giving NMN, which is the precursor to NAD, to people that are either obese or have pre-diabetes or even super fit ones.”

“Makes sense. The law makes sense. Where things got crazy was a company that I started called Metro Biotech started a clinical trial with NMN. And a little later, people started putting NMN on the market.”

“So now it is enforced? No, I mean the opposite. The FDA, I believe, says it's okay to have NMN on sale now. Oh, interesting. Okay. There was a court case that I think resolved that. Are you still taking the baby aspirin?”

“is low blood flow. And then we could reverse that with NMN through CERT1, more blood flow. And it's really underappreciated how much a lack of blood flow leads to diseases, especially your muscles and your brain.”

“and it had contamination. But I do want to say, at the risk of some litigious activity against me, that NMN and these NAD precursors can have contaminants in them.”

“NMN can have things like, well, first of all, I think the study that was published, it's worth looking at by Andrea Meyer. She's out of Singapore. She found that a lot of the NMN supplements didn't have NMN in it. And if they did, it was a low amount. And we found in my lab, which I don't think is in Andrea's paper, is that there is endotoxin in NMN bulk and supplements.”

“And we found out the hard way we were feeding it to mice to make them live longer, which is not going to work if it's contaminated. Hang on. So even the NMN that you were using in your lab that you thought was pure was so contaminated that it was infecting the study participants? 100%. Wow. So we've had to really work hard with manufacturers to get it really pure.”

“How hard do people need to work? If somebody's taking an NMN supplement now, is there anywhere that a normal person can go that's not going to risk being contaminated? Well, if I ever mention a brand, it's going to be, it'll blow up the internet, might bring it down.”

“regenerate what is that uh regenerate is uh uh like and and what is it nad or something like that okay yeah stuff like that and so it's nmn so it's like a precursor to nad yeah the ufc can find that stuff ufc provides it yeah okay so that means”

“Subcutaneous injections, they do it that way, too. Yeah. Yeah, but— But I think some of the best ways is actually NMN, that stuff, because what it does is it's like a precursor, and your body just makes more NAD that way. Yeah.”

“So some of this stuff, I don't even know what it does, and I'm just like, oh, it's for recovery. I'll do it, you know? Hyperbaric works. And it works in the same way that NAD and NMN work. Mm-hmm. Mm-hmm. Mm-hmm. It strengthens your telomeres. Like, they did this study out of a university in Israel, I believe it was, where they put”

“NAD boosters such as NMN, NR, hydration, electrolytes, and more. So all that said, I think we'll get into it with talking about family history. So we've talked about family”

“Why do I have to take this precursor, like nicotinamide riboside? So, maybe you could talk about why that is and also maybe just touch on nicotinamide riboside versus nicotinamide mononucleotide. That's another precursor. Yeah, yeah.”

“So, it's not that it's necessarily easier for nicotinamide riboside to get there. Oh, well, you asked about NAD and NMN, right? Well, yeah. NAD... So, NAD is not even getting inside of cells, essentially. You're taking it orally. There's a funny thing where people started injecting, right?”

“I thought NR got broken down to NMN. Well, no. NR gets phosphorylated, gets converted up to NMN. Okay. NMN has a phosphate on it. But that... So, it's a funny thing. Like, why, as a chemist, would you put a phosphate onto NR to produce NMN?”

“There are some reports that 17 out of 20 products labeled as NMN don't have NMN in it or don't meet... Meet the label claims.”

“Yeah, it doesn't work that way, though. Why doesn't it work that way? Well, it doesn't work because the NMN has a phosphate group that precludes its transport into the cell. So, in the 1980s, there were people that were developing nucleosides and bases as anti-cancer and anti-viral drugs.”

“That phosphate has to be put on inside of cells. So, if someone is able to find a safe purification... A pure form of NMN, which if you're at a drug company that is making and testing NMN, you could have access to that.”

“Right? If it just has the same chemical name, like if it's, you've read some study about NMN being done in a hospital in Boston or Tokyo or something like that, and then you go on Amazon and you buy NMN, you're probably not using the same material that was tested in that hospital. Right? And there's really no telling what's in it. Right?”

“They already had, they had pancreatic cancer and they gave them nicotinamide mononucleotide and it accelerated tumor growth. Is that ringing a bell? Um, no, but you know, there are, there are a lot of trials that you can do, things”

“study. It might've been out of Japan. Um, but it was definitely NMN given orally, no, no, actually it was given by, it might've been injected to mice with pancreatic cancer and it accelerated cancer growth.”