Pinealon

“And then all the, you know, people are thinking about biohacking with this as well. There's Pinealon, which I'll occasionally take and you get three hours of REM sleep that night. And on subsequent nights, your REM sleep is enriched. Interesting.”

“They didn't do the saline control, you know, but kind of hard to explain it away. Okay. Okay. So the other one is Pinealon. Pinealon is, ironically, is a peptide that doesn't come from the pineal, comes from brain tissue.”

“Epithalon comes from the pineal. Who names this stuff? It's like, it's insane. But I've experimented with Pinealon every third or fourth night, taking about a, you know, a tenth of an IU. And in those nights, those nights I get anywhere from two and a half to three hours of REM sleep.”

“I'm very interested. I experiment on myself and I'm an adult. I can do that. So Pinealon is very interesting because I found that if I took an itty bitty bit every third night, I tried this experiment for about a month, I got massive amounts of REM sleep that night, but also on subsequent nights.”

“Oh, I saw that episode. It's amazing. He's amazing. And I think you guys would have an even better conversation, frankly. But in any event, he tells me that Pinealon is potentially involved. There are some data supporting its use for encouraging pinealocyte health. So the actual health of the pineal.”

“Pineal gland. Yeah, the pineal gland, which makes melatonin and does other things too. So I think Pinealon is a great tool to use sporadically. I don't use it regularly. You know, as long as we're talking about peptides, I do think that there's, I mean, I'm peptide curious. You know, I'm from the Bay Area.”

“We also talk about peptides that have been studied for the purpose of DNA repair and longevity, like Epitalon and Pinealon, which also have been touted to improve REM sleep and for improving cognitive function.”

“Are they bioavailable active? Dr. Khavinson's work suggests that it is. Dr. Vladimir Khavinson is this Russian-Soviet scientist that gives us epitalon and Thymalin and Pinealon and all these Russian peptides. Di and Tri-peptides can be orally available if they're the right shape and size. They're not very well available, but they can be available.”

“If I take it at the beginning of the night, it reduces my deep slow-wave sleep and gives me far more REM across the night... if I happen to wake up in the middle of the night to use the restroom once or so... If I do a very small injection of Pinealon at that point, the one and a half hours of REM that I would get in the final hours of my sleep, now I'm getting three hours.”

“That on their own do a lot of the effects that the whole extract would do. Now you're talking about Epithalon, but pinealon and Epithalon. Is not from the pineal gland. Is not from the pineal gland. Even though everyone.”

“Tripeptide with no receptor... Previously called Pinealon, but from here forward, EDR.”

“They didn't have sleep trackers in the 1970s when it came to these. So there was no reports on that. But what seems to be happening, let's see, what is this Pinealon, this EDR? It's a tripeptide that meets the groove of the DNA of different key regions and helps the promoter region be exposed. So then that DNA transduction can happen, translation, transcription.”

“Okay. But if you take it in the morning or pre-HIIT workout, you get quite an interesting effect. So he studied this compound on athletes and he would have them do their training session, go to exhaustion, and then do a test afterwards. And there's two groups, Pinealon and the placebo. The Pinealon group could keep their performance up despite being maximally exhausted from their training.”

“Now I know it's cleanly sourced because I trust the compounding pharmacy it's coming from. But I should ask, are there any known risks of EDR? So far, nothing in the Russian literature. So big caveat, it's Russian literature. It's not gold standard American research that we love here. So there's nothing that's come up as a clear sign.”

“For some people, that could be disheartening if they have like, you know, nightmares or something like that. But very, very vivid dreams as a result of pinealon. Especially like the color and the quality of the dreams is very different than you normally expect. What seems to be happening is like, just like, you know, psychedelics change the redox state of the brain.”

“So is that distinction going to apply to peptides also? Is the big question that no one's answered. And is a, you know, Pinealon is a supplement you can find in Kazakhstan and Russia and Ukraine, wherever, all these different countries, over-the-counter in different pharmacies. Is Pinealon available as a capsule? It's available as a capsule. Does it work as well as a capsule?”