Dr. Martin Picard: How Stress Physically Drains Your Cells, Why You’re Tired & How to Reverse It

“And the question that they know you personally lean on lifestyle interventions. But the biohacking community is very interested in compounds like methylene blue, urethylene A, and NAD plus boosters. In your opinion, what does the sort of...”

“To the electron transport chain. So the mitochondria can flow those electrons with low resistance. So if you're depleted of NAD, that's going to cause increased resistance for electrons to flow through this metabolic circuit. So NAD plus seems to calm things down a little bit in terms of energy processing.”

“And it makes people... Feel more energetic. Is that in pill form? Like, how do people take NAD plus? Because I know there was some like drips one time that some guy gave me. Yes. I think there's oral supplements that are precursors to NAD. If you eat NAD directly, it doesn't... The bioavailability, it's called, it doesn't get into, you know, your cells very well.”

“Yeah. And so the term mitochondrial dysfunction is, I think, a little misleading. Like there was a lot of hype about NAD. There was a lot of hype about coenzyme Q, CoQ10. There was a lot of hype about all sorts of things, anti-inflammatory, you know, berries and antioxidants was a big thing 10, 20 years ago. Turned out not to be so useful.”

“and normal healthy people as well who feel more energy. What about this urolithin A? Urolithin A is a new compound that seems to stimulate the degradation of bad mitochondria. So we talked about autophagy, mitophagy earlier.”

“during exercise. What urolithin A seems to do is to kind of accelerate this process, right? So it accelerates the degradation of the bad mitochondria, the mitophagy, so that the cell has to make more of the good ones.”

“Like, there was a lot of hype about NAD. There was a lot of hype about coenzyme Q, CoQ10. There was a lot of hype about all sorts of things, anti-inflammatory, you know, berries and antioxidants was a big thing 10, 20 years ago. Turned out not to be so useful. Actually impairs normal adaptation and signaling if you eat too many antioxidants.”

“beautiful story. And this, the sociality of mitochondria in the organism, the liver mitochondria is where ketones are made. If you eat fat, right? Avocados and oil and meat and butter and those fat molecules and go in the liver and then the mitochondria in the liver take those fat, transform them into ketones and then put the ketones into the blood.”

“Like, there was a lot of hype about NAD. There was a lot of hype about coenzyme Q, CoQ10. There was a lot of hype about all sorts of things, anti-inflammatory, you know, berries and antioxidants was a big thing 10, 20 years ago. Turned out not to be so useful.”

“grain-based diet would cure ingestion and improve overall health. He co-invented Corn Flakes, and he and other cereal pioneers pushed the narrative that a healthy, cold cereal breakfast was essential for a productive day. And your dad bought it hook, line, and sinker.”

“eat something fatty and sugary. Especially the sugar part. Then you, you lose regulation. And that's why I think the GLP-1 drugs are so powerful because they, they address the problem where it starts. Like how much food are you putting into the system?”

“one of the things that I remember Johann Hari saying to me, he wrote a book called Lost Connections is that in some cultures the cure they apply for depressive symptoms is, giving someone purpose in their life.”

“And the question that they know you personally lean on lifestyle interventions. But the biohacking community is very interested in compounds like methylene blue, urethylene A, and NAD plus boosters. In your opinion, what does the sort of...”

“sunlight. And listen, most of us live in such a dark bunker with very little sunlight. So we then have to take vitamin D. So because we live outside of our true nature, I'm wondering if actually we do need to take some supplements because we're not going to heal. We are going to heal.”