Resveratrol

“How do you shut it down? Well, it turns out these first two things we talked about, NF-kappa-B, NRF2, if you take these supplements with curcumin, broccoli seed extract, resveratrol, by the way, is also a great NRF2 stimulator.”

“I only had two people in the hospital, and they were both immune deficient, by the way, for COVID. But when you stimulate NRF2 with curcumin, resveratrol, broccoli seed, green tea extract, you take NaC alpha-lipoas glutathione. You take LDN, melatonin, and a multi-mineral supplement, very important.”

“So in the morning, and if you go to page, what is it, 304 of lifespan, it's still there. And I still do that. Resveratrol. It's been back and forth, controversial. It's not controversial in scientific circles. There's a few naysayers, but they make a living out of it. Resveratrol is from plants that are stressed and they activate CERT1, this resetter and slower of the epigenome noise.”

“noise. So I've been taking about a teaspoon, call it a gram of resveratrol every morning, almost every morning for the last, gee, probably 20 years. Doing all right. It seems to help in clinical trials.”

“We'll see what they say. What was the controversy? Because I know since the last time we spoke, there's been some furore around resveratrol, some more furor around NAD, maybe NMN as well. Yeah. Can you explain what happened? Yeah, sure. These are all typhoons in a teacup or whatever it is.”

“I can't stop drinking your drinks. Very good. Good. That's all I needed. So let's start with resveratrol. I try not to bore everybody. SERT1 is an enzyme. I'll use my hands. It's an enzyme that carries out reactions that stabilize the epigenome so it doesn't decay.”

“You're old enough. So it's chewing away the chemicals, stabilizing things. Faster, the better. Resveratrol, we know, binds physically to the enzyme and now makes it chomp faster. Okay. The controversy that came up was that Pfizer, a team at Pfizer, not the whole company, just a group in the company, put out a paper in 2010 that said, Resveratrol doesn't do this.”

“We could even block it by changing an amino acid in this protein. And we actually have a study now that we've made a mouse that has this block, and resveratrol doesn't make the mouse healthier anymore. It doesn't live longer. So that's as good as evidence that you could get that we were right in the first place and Pfizer was wrong.”

“And I think there's a lot of individual variability there as well. I know resveratrol is something that's talked about a lot. And there's, you know, suppose there's in wine and grapes, there's resveratrol and that's been linked to enhanced health and well-being.”

“star and you took NAD and felt nothing. This is why resveratrol cleared up the skin of a friend of yours and you take resveratrol and nothing happens. So every human being has this exact methylation cycle, but we all have different deficiencies.”

“Right. Everybody's looking for the quick fix pill. Yeah. It's not going to be a resveratrol or an NED or you got to work. The ultimate human works, right? Like I see what you do here. You walk around this place. You live it. Oh, yeah.”

“You actually have resveratrol and turmeric, another good bioflavonoids in there, right? So, there's a company out there, the company name is A-Lite. My mentor, Dr. Jill Christa, she formulated that thing, that entire supplement just for mycotoxin purposes.”

“And in McDermott et al., and I believe that she's the top peripheral artery disease clinical trialist in the country, she's at Northwestern, did a three-arm clinical trial, placebo versus nicotinamide riboside versus NR plus resveratrol, and found that the NR arm improved their six-minute walk test.”

“And the placebo arm, as well as the NR plus resveratrol arm, degraded their six-minute walk test. So the resveratrol not only was not helpful, but it actually blocked some of the benefit of supplementing with NR.”

“When it comes to taking nicotinamide riboside, these NAD precursors, you mentioned stacking it with resveratrol, which is a type of polyphenol, that it's sort of negated some of the benefits.”