295. Methylation Test & MTHFR Gene - Healf Experience Wellbeing Event 2026 in London

“And creatine because, not because creatine is a bodybuilding supplement, which is kind of the category it's been in for decades. What's really fascinating that we knew 15 or 18 years ago in the mortality space, what's really fascinating is the way the human body works is we take certain nutrients, like vitamin B12.”

“But from the same amino acid as an egg protein. So what's fascinating is, you know, when we talk about creatine specifically, it is a part of this methylation cycle, and it is absolutely critical to something called SAM-E.”

“SAMe is the main, the number one methyl donor in the human body. When you become deficient in creatine, which your body does produce, but when you're deficient in this nutrient, it converts SAMe. It actually eats it from SAMe.”

“So when the body is deficient in certain nutrients, why you're seeing creatine now topping the charts for cognitive function, why you've probably heard me say that every woman over 40 years old has to be on a creatine supplement, why you're seeing it now creep into neurodevelopmental disorders, mood and mental illnesses, because this compound is a substrate that is made in the human body,”

“methyl donor in order to produce creatine. And so what's fascinating is when we go into the human body and we look at all of these compounds, if I keep zooming in on this chart, most of you are going to recognize these.”

“So, if you have uterine fibroids, I would highly recommend that you get a Dutch test done. Because a Dutch test will actually look at the entire complement of hormones and it will look at all of the precursors. If you're deficient in pregnenolone, you have all these downstream consequences with cortisol, with aldosterone, you have your sleep-wake cycle off, you”

“Again, I would go back to the gold standard test called a Dutch test. And in this test, you are going to see the entire cascade of hormones. And you are going, yes. You've done it? Thank you.”

“So when you see that these get out of ratio, it causes other consequences. The thing I love about this Dutch test, and by the way, I sell in the Dutch test hard. I have no affiliation with the Dutch test. When you see these ratios, what I love about this test is it sets these dials.”

“Yes, ma'am. Yeah, now you. Who's got the microphone? Hi, so I've done a Dutch test, and actually it showed that I metabolize the hormones very slowly or low. So all my hormones are low, and then my cortisol kind of like wakes up in the morning, but straight away it goes down.”

“Their deficiencies are genetically inherited. One is selenium. The second is selenocystiene. And the third is selenomethionine. And I could take you right into this chart and show you exactly how those are methylated.”

“then your body can now take selenium, which comes into the body. You could take a selenium supplement, convert it to selenomethionine, convert that to selenocystiene, which is the catalyst for that transaction.”

“And again, that gene test could potentially change your life, at least change your thyroid. I supplement selenium, but I need to get the specific, make sure that it has all three forms. That's where we go wrong, right? Because selenium is where it starts. Selenium gets converted to selenomethionine.”

“that you put it in? Selenium enters the human body. It's not used as selenium. It's converted to selenomethionine and then to selenocysteine. It's the selenocysteine that deiodinizes T4 into T3.”

“And it is a nutrient deficiency. It is the inability to convert folic acid and folate into something called methylfolate, the gasoline that your body needs to run. This is why I have never, in 10 years of doing these talks and of owning a functional medicine clinic, I have never once met a single person that suffers from anxiety that didn't also have gut issues.”

“These two are inextricably linked by the same nutrient deficiency. When you're deficient in methylfolate, the peristaltic activity in your gut is impaired. The methylation cycle for serotonin and dopamine is impaired. And you have a mood disorder.”

“So if you are deficient in the complex of B vitamins, you're deficient in methylfolate, you're deficient in trimethylglycine, TMG, then your body can now take selenium, which comes into the body.”

“If you don't find the deficiency, nothing else matters, which is why your sister took NAD and she felt like a rock star and you took NAD and felt nothing. This is why resveratrol cleared up the skin of a friend of yours and you take resveratrol and nothing happens.”

“I'm a huge fan of NAD. Delivering it through the gut requires a liposome, right? Or else it's destroyed in something called first-pass metabolism. Or you can inject it or you can do it in a patch, or you may be able to do it sublingually. But if you're going to put NAD into the body and get it through the stomach, you need this liposome. By the way, I don't sell liposomal NAD.”

“Now it has to go into the mitochondria and then it exerts its effect in the electron transport chain and the Krebs cycle. But the amount of cofactors that are needed to target direct that NAD, things like phosphatidylcholine, trimethylglycine, if you don't have those cofactors, you've gotten NAD through the gut and you've dropped it into the gut.”

“But what I have found works very good to lower lipo-little A are three things. The peptide thymosin alpha and a combination of bergamot O, which is a citrotyl extract, and slow-release niacin. Make sure that you take the slow-release form of niacin, and it is one of the most effective ways.”

“15 to 30% reduction in lipo-little A, which there's no pharmacological solution for. So if I had elevated lipo-A, which I do, I would be taking slow-release niacin, bergamot O, and consider the peptide thimosin alpha.”

“So we're getting to the raw material. The body is going to break that protein, whether it is collagen or fish or egg or plant protein. It is eventually going to turn that into amino acids. And then amino acids are going to go build structures in the human body.”

“We don't eat our nails to grow our nails and we don't eat our hair to grow our hair. And we don't eat collagen to grow collagen. Collagen, like any other protein, is going to turn into amino acids. And yes, if your body needs collagen, elastin, fibrin, it can build those structures.”

“Munir, Chloe, thank you so much for the SMOOV collaboration. I gave one of these to all of you guys. It's got trimethylglycine in it and other methylated nutrients. I hope you enjoy it. Thank you, Smooth. Guys, we're going to have some fun today.”

“So if you are deficient in the complex of B vitamins, you're deficient in methylfolate, you're deficient in trimethylglycine, TMG, then your body can now take selenium, which comes into the body.”

“What else is going to skyrocket? Estrogen. Your estrogen level is going to climb, which is very often why they pair hormone therapy, testosterone, with aromatase inhibitors like Anastrozole or Exemestane or Diindolylmethane, DIM to try to control that aromatization of testosterone.”

“So if you are deficient in the complex of B vitamins, you're deficient in methylfolate, you're deficient in trimethylglycine, TMG, then your body can now take selenium, which comes into the body.”

“What else is going to skyrocket? Estrogen. Your estrogen level is going to climb, which is very often why they pair hormone therapy, testosterone, with aromatase inhibitors like Anastrozole or Exemestane or Diindolylmethane, DIM to try to control that aromatization of testosterone.”

“And it is a nutrient deficiency. It is the inability to convert folic acid and folate into something called methylfolate, the gasoline that your body needs to run. This is why I have never, in 10 years of doing these talks and of owning a functional medicine clinic, I have never once met a single person that suffers from anxiety that didn't also have gut issues.”

“Most have done a GI map, so they have checked their gut microbiome. If you haven't, a good GI map stool test would be an excellent place to start. What they have overlooked, in my opinion, is the most overlooked thing in all of bariatric medicine.”

“And when we landed this morning, my wife's like, what the hell are we going to do? I was like, I don't know. Give me some ginger. Guys, these are amazing. Munir, Chloe, thank you so much for the SMOOV collaboration. I gave one of these to all of you guys. It's got trimethylglycine in it and other methylated nutrients.”

“But when your T3 is low, there's an 80% chance it's not the thyroid. Yet in 100% of the cases, we put you on thyroid medication, levothyroxine, synthroid, Armour Thyroid. So the question is, where does the other 80% come from?”

“You also have sleep and circadian dysrhythmia. If you, I'm going to actually give you that methylated multivitamin. So just go to the booth after this. I want you, I'm not kidding. I want you to take two of those in the morning and one at night, trimethoglycine, and that sleep formula.”

“Now it has to go into the mitochondria and then it exerts its effect in the electron transport chain and the Krebs cycle. But the amount of cofactors that are needed to target direct that NAD, things like phosphatidylcholine, trimethylglycine, if you don't have those cofactors, you've gotten NAD through the gut and you've dropped it into the gut.”

“star and you took NAD and felt nothing. This is why resveratrol cleared up the skin of a friend of yours and you take resveratrol and nothing happens. So every human being has this exact methylation cycle, but we all have different deficiencies.”

“Make sure that you take the slow-release form of niacin, and it is one of the most effective ways. 15 to 30% reduction in lipo-little A, which there's no pharmacological solution for.”

“Right? So I would really encourage you to get heavy metal toxicity testing. Probably the best one is a urine test called a vibrant wellness, or you can get a provoked heavy metal test, which is where you do chelation and then collect urine for the next six hours.”

“the human body works is we take certain nutrients, like vitamin B12. We take that vitamin and it gives its life to the conversion of one nutrient into another.”

“and topical vitamin D, of course, a lot of supplements, including vitamin D, high doses, and red light therapy. Yes, good. It has improved so much. Yes. But I want to know from your point of view, which one of all of these that I've done has been the cause of this improvement.”

“A large percentage of your brain is cholesterol. Cholesterol is how we make vitamin D3, sunlight, and cholesterol, the only vitamin that a human being can make on our own. Cholesterol is a necessary construction material. It does not just randomly and inadvertently jump out of the bloodstream and stick to the arterial wall.”