“the miracle one at all of them that you don't lose muscle. Tetrutide or Retatrutide, depending on how you want to put it. So it went through phase three trials. So as of the recording of this episode, it's not FDA approved yet, but it probably will be. And it did cause a little bit more weight loss than the generation two Tirzepatide or one, you know, Semaglutide.”
“I was doing weights for over an hour, six days a week, and long cardio once a week. I scaled back this summer to five and I was doing some sporadic Retatrutide, but then stopped because I was losing too much weight. Well, the time I wrote this, I was 119 pounds.”
“They wouldn't know. They'd just say Ozempic is Ozempic. And then that's funky too, because I don't know how you feel about, actually, I would imagine I know how you feel about Retatrutide, but it is just a thing that beyond, or of course I'll change my opinion if a certain study comes out revealing this crazy side effect, which there's no leads of yet.”
“Here's the thing. I started taking Tirzepatide, which is like. Yeah. Ozempics big brother, but not, but like still a little brother to whatever the Retatrutide thing is that Eli Lilly hasn't released yet.”
“And you can buy online peptides that may be the same as Retatrutide. They might not. You have no way of knowing. Yeah, and in many ways, that's the premium you're paying when you're buying the drug from Novonordisk or Eli Lilly or Novartis or whatever is.”
“Okay. But you got to ask them. I see. So publicly, the only thing we know is they're still doing something with it, presumably testing it with Tirzepatide, I'm guessing, or Retatrutide. The study that's in clinicaltrials.gov is a complex combination study with terzepatide.”
“It's not quite as potent. People think of it as Batman and Robin with GLP-1 and GIP, right? People might be curious to know that this drug, Retatrutide, that the more cavalier peptide curious folks are already getting off from compounding pharmacies and gray market, black market.”
“need help, but there were a lot of side effect issues. Then along comes this other drug, retatrutide, which is like, okay, well, let's increase GLP, but let's also kind of bump up the GIP system a nudge or two. Let's also bump up the glucagon system. And lo and behold, we get a much better effect, muscle sparing, and actually better weight loss.”
“Like Retatrutide is going to come out from Lilly, make them billions, if not trillions of dollars. They're working hard to protect that patent. But you can bet people who are getting prescribed real retatrutide from Lilly will be taking less and sharing it based on information they hear on the internet from the peptide community and on health podcasts because, and that scares the shit out of them.”
“But if people are taking itty-bitty bits of Retatrutide, and to be fair, if people who didn't do all the preclinical work are selling it and making profits, I understand that siphons profit away from Lily. They have a reason to be pissed and scared.”
“And again, I don't think body fat is the major problem. I think it's intramuscular fat. That is true. That a lot of the studies on, I think it was primarily Retatrutide that showed muscle loss were done via DEXA evaluations, which couldn't differentiate between lean mass loss coming from muscle or lean mass loss”
“You know, I'm from the Bay Area. I'm called peptide curious. I have not tried any GLPs yet, but I'm getting curious about very, very low dose Tirzepatide or Retatrutide. I'm peptide curious, but I'm scared. Yeah. I'm scared because I don't, you've got to inject most of them, right?”
“So the GLPs, which are the weight loss drugs. The weight loss drugs. I think Retatrutide is amazing. It's not just a GLP. It also hits the glucagon and GIP pathway. This is the one that Lilly invested. Eli Lilly invested hundreds of millions of dollars, if not more, into researching.”
“Well, do you want to be in the experiment or out of the experiment? You want to be in the control group or you want to be in the experimental group? Well, for somebody who has like serious obesity issues, the tirzepatides and Mounjaros and Ozempics and retatrutide could potentially save their life. Okay. Vision loss is a serious consideration.”
“And we'll have to come up with something else to discover. Something sexy. Huberman says he thinks Retatrutide will be a trillion-dollar drug. Do you reckon about that? I think it's possible. If the oral ones really look good, they may actually be even more interesting.”
“that are giving people smaller doses and less. Then there's the Retatrutide stuff. Am I saying that right? Retatrutide. Retatrutide. Retatrutide. That one is a weird one because that one allows you to keep muscle mass.”
“Many peptides come with a powerful story around them. That's true for something like Retatrutide, and it's also true for something like BPC-157. The difference is that for some peptides, controlled human trials help separate the effect of the molecule from the expectation surrounding it.”
“This is, I would say, a not obvious point. Take Retatrutideas an example. Retatrutide is not just the amino acid sequence.”
“polypeptide. Two signals instead of one. The metabolic effect was stronger. Weight loss numbers climbed. And then came Retatrutide, which is a triple agonist, GLP-1, GIP, and now a third, the glucagon receptor.”
“And they're like, Should I be taking low dose? Should I be microdosing Tirzepatide or Retatrutide? I'm like, Retatrutide is not even released yet. They're like, where can I get it? Like, are you kidding me? You know, but it's like, it's incredible what's happened in the last few years.”
“Yeah. They're not the super popular ones. I think the super popular ones are, besides the GLPs, and Retatrutide is a GLP and other things, but I would say, microdosing of Retatrutide and Tirzepatide, one category for weight loss, fat loss.”
“the initial insights of the effects of Retatrutide, which is a drug I'm sure many of you have heard of as it's making its way through the... peptide cesspool at the moment”
“now again i don't have the numbers on this but with Retatrutide and the other GLPs. I've never tried them, but a lot of people are finding it much easier, if not easy, to lose weight”
“So Retatrutide, is that how you say it? I believe so, yeah. So that, the difference between this retitrutide, this one is a different one in that this one allows you to, you have all the weight loss, but you don't lose the muscle loss.”
“Holy hell, bro. If this Retatrutide, am I saying it right? Retatrutide, Retatrutide, whatever it is, this one, they think, is going to be incredible because this one is going to give you all the fat loss, but none of the muscle loss, none of the bone density.”
“in CEOs and celebrities and stuff is using a combination of those three things. You know, your TRT plus Tirzepatide or Retatrutide, whatever it may be, and then using a growth hormone modulation if you can afford growth hormone or Tesamorelin and Ipamorelin. And you're seeing people lose a lot of fat, gain a lot of muscle in short amounts of time.”
“The raw materials, like the semaglutide you're getting from a compounding pharmacy or a research peptide website, Retatrutide included, comes from China and then gets either the raw material gets packaged here into the vials. Wait, raw materials or synthesized compound? Because there's a big difference between getting like the raw materials for something and getting the thing.”
“This is the problem with peptides. This is what Eli Lilly is coming into when it comes to making RETA is that patent laws for peptides kind of suck because you can add on one amino acid, you can modify one thing on it and suddenly it's a different compound.”
“And I'm guessing that for women... The... It's the combination of growth hormone secretagogue plus something like... And we'll talk about these now. Retatrutide or one of the other GLPs.”
“What happens to all these young kids that are 18, 19 years old on five milligrams of Retatrutide that have lost 30, 40 pounds are they going to have to be on that for life now to maintain that weight?”
“the newer ones the effects are much less like the people report Tirzepatide and retatrutide even have less of these gastrointestinal effects but um that's a peptide gone wrong story. peptide gone wrong”
“i did still think that it that Retatrutide is going to be a trillion dollar industry not because so many people are necessarily going to use it for weight loss but because many people will use it for weight loss”
“Retatrutide is going to be one of the most successful drugs in history. For sure. One of the most widely used drugs. Uh Scott Galloway has the uh idea he says it's the America's the best place to earn money and Europe's the best place to spend money.”