BPC-157

“All peptides help soft health. Your body produces it, so it's a natural part of your body. And you add BPC 157 to your body. If you have soft tissue injuries, you will heal quicker. Anecdotal, but also true. Taylor DeLong was telling me about it, and Will took it, and Will said that he blew his hamstring out, and he took it.”

“and all that other jazz but i'm sure he's on all that stuff too right i mean if he's not i'd be stunned like why wouldn't you be that's crazy you know why wouldn't you be on bpc 157 and tb500 and he's and if you're allowed to be you should definitely be on testosterone and definitely be on some sort of uh human growth hormone”

“prohibited. But what about BPC 157? Specifically that one. BPC 157 was weird because it was allowed by WADA and then it was banned. It should be allowed. All it does is regenerate tissue, or rather help heal tissue. It's banned. Banned in NBA.”

“And what that treatment was was not really publicly talked about. But people were saying, you know, get them on stem cells, get them on BPC 157. Right. Get him back so he can play. I don't know if they are doing it. They have to take time off so they can hide from the future. Right. Sort of like Connor did when he broke his leg.”

“banged up. You're getting banged up. And BPC-157 would help those people. But they're also doing, there's a lot of stuff these guys are doing now. A lot of guys are invested in hyperbaric chambers. They're doing a lot of hyperbaric therapy, which really does accelerate healing from injuries and just general just general overall recovery from just life itself.”

“You know, like when you years ago were like, oh, I hurt my Achilles. And so I injected BPC whatever 157 in my, and it's, and it's healing my Achilles. And I'm like, that's a crazy thing to do. You're like, no, it's the Wolverine stack or whatever.”

“All they do is help soft tissue injuries. BPC 157, I think, would be an easy one to approve. That's the best one, I think, for soft tissue injuries. Have you used them? Oh, yeah, fuck yeah. I use the shit out of that stuff. That's massive. Everyone always tells me Wolverine stack.”

“You know, they own a compounding pharmacy. So you know that you're getting an actual pure version of BPC 157. Whereas if you order it online, who knows where it's coming from? You're getting it online. It's getting delivered to you. It might be coming from China.”

“And it's not just cold plunges and saunas and massage. BPC 157 will help them recover. And it's not going to make them a super athlete. It's not going to make them faster or stronger. It's just going to help heal injuries. Right. I mean, that's my position. But I think it's weird that you can use some things that work great, like creatine.”

“I lived through the tercasterone era. Yeah. So it's just the thing. But it's like, you know, every time I like, I've just got BPC and TB500, like just at all times. What's your experience with peptides? What have you found to be useful? Definitely those two for sure.”

“My shoulder's out of whack and I hurt my rotator cuff and my golf swing hasn't been the same. I started doing BPC for two weeks and now I'm back. And like that's kind of the extent of it. But it just gets overhyped, you know, because now, I mean, you get all the TikTok kids and like literally kids.”

“what they do are almost non-existent. I've been reading in the popular literature about this one that's, I think it's called BP197. BPC 157.157, yeah. All of the data for that peptide come from one investigator who's the only person published on it.”

“There's a lot of grift in the health and wellness industry. You're not insulting me. But that's my point. Despite how much grift there is in the health and wellness industry, I'm putting BPC 157 on the podium, at least. I would too. Yeah. I would too. Okay, so we've made Bimagrumab and it's made it through all of the IND enabling study activities and we're ready to give it to people.”

“me like, hey, man, my knee, is this BPC-157 stuff going to work? And I go, I don't know. You can try it. I know some clean sources of it. And then they'll come back a week later and like, why isn't anyone selling this, studying it, talking about this?”

“They're genuinely interested in helping people. You see two, it's two camps. So when I hear people saying, oh, yeah, this BPC, no trials, okay. Are there any adverse events we need to know about? Not that I'm aware of. And Abud says, you know, the lethal dose is like super high.”

“And I like, yeah, put two injections of BPC, gone, gone. Now, could I put saline in there and it would have been the same? Maybe. But all I know is it's gone.”

“me with chronic fatigue? Should I be taking BPC? You know, people will ask these questions. I'm thinking, well, if these people are asking the question, that means people around them are asking it. It's starting to become okay-ish to have these conversations.”

“Like, what is this? Maybe I need to back off. And it's like, you know what? Like, it's pretty bad. I'm going to just put two injections of BPC in there. So two injections of maybe 100 or 200 micrograms, tiny amounts, right? Gone. History. Can't find the pain.”

“That's pretty incredible. The animal data are really impressive. And I know a number of people with pets, dogs in particular, who've been injecting their animals with BPC because their dogs are getting older. I don't want to name names here because I haven't cleared it with them, but they have dogs that either had spinal strokes or just aged and were limping and not doing well.”

“for the immune system. Yeah. I keep around BPC 157 and TB500 for injuries. I run a couple of times a year, a Tesamorelin, Ipamorelin with CJC 1295 cycle for growth hormone.”

“We submitted over 800 studies, 800, 5,000 pages of documents. We did a retrospective analysis of 16 million patients that were on BPC 157. Out of that, we found three adverse events. Three adverse events. Yeah.”

“And I think that's great. So actually on BPC, we submitted, I think, four or six human studies. I can't remember. I don't want to tell it. Let's say four to be safe, at least four human studies. Now, the issue with a peptide is you cannot patent something that is readily available in nature.”

“They give me a ton of deep sleep. I don't like them. I've tried Pinealon. I'll take it now and again. I don't do it right now. And BPC is the one that gets everybody talking because body protection compound 157 is made in the gut. People claim, and I do think their claims are accurate, that they feel, notice what I said right there, is they feel as if their recovery from injury was accelerated.”

“You should ask, what effect in your life are you trying to achieve? Right. And then maybe BPC makes sense. Maybe it doesn't. You're not going to find many clinical trials on it. It has a very, very high, maybe infinite, you know, LD50, meaning no one has really figured out how much can kill you, but that's not a good kind of way to run your life.”

“And it's helped my help the dog a lot. He's BPC 157 for his hip dysplasia. You could noticeable difference in the pain that the dog had walking around. Now it's actually pain-free. And like I say, it's going on 17 years or going on 18 years.”

“And most that end up showing clinical benefit do have that. With BPC-157, we do not have a clear mechanism as well. Okay, so what's the second question? Is there evidence of meaningful benefit in humans?”

“Now, of course, that doesn't prove that BPC 157 causes cancer, and I'm not saying that. But if proponents claim that it meaningfully stimulates healing through those pathways, they should also take seriously the possibility of stimulating biology you may not want overstimulated.”

“Fifth, is there a better characterized way to get the same result? Well, for BPC-157, you do not need a perfect named alternative to reject it. You're being asked to take an uncharacterized molecule on faith. For tendon injuries, ligament injuries, pain, inflammation, gut symptoms, or recovery, there are better characterized ways to evaluate and manage the specific underlying problem.”

“Many peptides come with a powerful story around them. That's true for something like Retatrutide, and it's also true for something like BPC-157. The difference is that for some peptides, controlled human trials help separate the effect of the molecule from the expectation surrounding it.”

“For others, like BPC-157, the story is powerful and the human outcome data are thin. Even when a peptide is biologically active, the perceived benefit can still be shaped by expectation, behavioral change, and the ritual of treatment, along with the broader story attached to it.”

“halfway between pharmaceutical and supplement. Um, anyway, BPC 157, TB500, Thymosin Alpha, and SS31. So, um, recovery and gut, more recovery because I had a tooth extraction a little while ago and I'm trying to regrow a bone in my face.”

“You can lengthen your telomeres with telomerase-lengthening peptides like an epitalon. You can actually reduce inflammation by putting peptides like BPC-157 into the bloodstream, TB500 into the bloodstream, and actually accelerating wound healing.”

“Mm-hmm. Like I had a guy in the office the other day who had rotator cuff tendonitis. We put him on BPC-157, TB-500. He texted me a month later. He goes, I'm 80% better. Really? So it's incredible. And then I have my own story about peptides. So I had all these patients on peptides.”

“And you went to Ways to Well. They treated your foot with stem cells. And they injected BPC-157 into your foot to help your foot heal. Yeah. Is it healed now? Is the bone fused up? Yeah. What did it do? It just grew back? Yeah, finally.”

“And when they put in the BPC there that that one time in November. And so that was like that was a thing. And all I said, you know, I had a very fast year.”

“And I get that. And it's kind of why I've waded into this and said. I'll be the poster boy for this. I'll admit that I took BPC-157 to try to avoid surgery on my foot. And whatever the fallout is, is what it is because this needs to be discussed because”

“There's no mention of it. But it's also what the, the thing that. That doesn't make any sense is, first of all, BPC-157 is not a performance enhancing substance. Yeah. It helps heal soft tissue injuries. It's very good for recovery from injuries. That's one issue.”

“But for him, I was on the radar for a few different reasons. This gave him like the reason why like BPC 157 is banned for Olympians, not for a regular person. Regular people can take it.”

“That's fine. I would be like, oh, that was my bad. I didn't do that. They never mentioned it. So if somebody said, like, I didn't know BPC was banned for Olympians at all before this. I just thought that it was another, maybe you could get a TUE for, or I didn't even know what TUE was, but because I just, it's not my world.”

“Yeah, I've done stem cell, I've done TRT before and mentioned BPC-157”

“I've done TRT before and mentioned BPC-157. And it's like, I didn't know when that was, but I just kind of, because he was like coming at me, I'm just like, no fuck off. It's like, I do all this. I don't know whether it's approved or not. It doesn't. It has nothing to do with me.”

“Well, he got what he needed because admitting to taking BPC for like Olympian is a huge deal because it's banned just for them, not for me.”

“taken BPC since then, um, it's just, it's kind of just, I think all you can do is state your case and I think you just did and you just did it really well and I know you and I can. I can speak for you.”

“Like this is fucking insane. I would have never done the redo knee. I would have waited. Shot it with stem cell. BPC'd it. At that time, I was still a little fearful of needles. So I was like, ah, BPC them. Everything is you got to shoot it. You're fearful of needles but not of a knee replacement.”

“Ozempic, Monjaro, and Retatrutide as well as peptides such as Body Protection Compound 157 or BPC-157, which, as you'll learn today, has a very long history of being used in humans for gut health and tissue repair and many interesting studies in animals supporting its potential use in humans, but a minimum of formal studies in humans.”

“but a minimum of formal studies in humans. Meaning, one. We discuss BPC-157, what it does and how, as well as things like growth hormone secretagogues like Tesamorelin, MK-677, and others. And we talk about things like GHK copper, which nowadays many people are using to promote collagen synthesis and repair for aesthetic reasons, like improving skin, hair, and so on.”

“Now we've been looking into animal tissues to find cures, medicines, treatments. So a group in Croatia in the 90s looks out for this peptide called BPC, that they eventually named BPC. It's a 40,000-dalton, giant peptide called BPC.”

“BPC-157 is 15 amino acids from that giant peptide. We don't naturally make BPC-157. That's what you'll commonly hear online. We make BPC the big protein. Did this group go looking for a body protection compound?”

“what's causing the actual biological effects? They identified BPC-157, the 15 amino acid peptide that's causing all these effects. There's actually more peptides in gastric juices that some other scientists may or may not have already identified. This field of peptides is going to be very interesting because almost every organ has a signature of peptides.”

“interesting way. We'll have people come to us and they're like, my Adderall is not working since I've been taking oral BPC. Are they happy with that effect? No, they're not happy. They're very mad because it seems like it's blunting their Adderall. So it's doing something from dopaminergic signaling on both sides, both withdrawal when it comes to the gapinergic side, but also the peak”

“No, no. I think that story was hearsay. I don't think they wanted to reveal what they actually did. I don't think they only did BPC 157. They'd be stupid if they did. They should have all the best and latest, greatest treatments, whether exosomes, stem cells, other peptides. Anything that wasn't banned. And by the way, I should say BPC 157 was not on the banned substances list at that time.”

“Like the gray market existed for the last 15, 20 years. Bodybuilders would, you know, have anecdotes about BPC-157. They'd inject it post, you know, post squats for different injuries. Nobody really cared about it. It was with the GLP-1s and then the banning of the peptides, plus this, you know, anti-medicine kick that's been happening over the last five years.”

“So in the liver, it had a signal of cancer in animal data. So that whole thing was scrapped. There's no signal from the animal literature on BPC-157 for, you know, cancers. Now, all that literature comes from one group. So we have to be very careful. It's that one creation group that tells you that it's the safest thing in the world.”

“Really? Yeah. Humans. Yes. Phase two. Yes. We talked to a group, an orthopedic group somewhere on the East Coast. They wanted to do a BPC trial so that we consulted with them to kind of... Great. Yeah. So it's going to happen. Especially if it moves to this category one list and people can be prescribed it. At least we can get, like, a phase four trial where it's being prescribed and we can see”

“They're making tons of money making Adderall. They don't really care. They don't care about BPC, 157. So they have one of the patents. The other patent expires in like 10 years. I think Sikorek still has it. Dr. Sikorek is the guy behind BPC, 157. He's in Croatia. He's in Croatia, yeah. Would Teva sell the patent?”

“you could do a trial on like, you know, GERD. That's a simple condition. A lot of people have it randomized to, to BPC-157 oral capsules versus pentoprazole. Okay. And you're basing this on the fact that you've seen and heard that people who have GERD get better, feel better when they take it. Okay. And it could be placebo. Yes.”

“the prostaglandins, you know, all these different hormones that are made, potentially BPC-157 is part of this robust armory that the gut has to protect itself from further injuries. What are some things outside the gut or indirect from the gut that are also compelling? So I would love to see some neuropsychiatric BPC studies when it comes to addictions.”

“that was not gray market. It was obtained through a doctor's prescription from a compounding pharmacy. Yep. Labeled BPC-157, but not PDA. Not PDA. Okay. Those are anecdotes. I've also read, just to be fair, we should balance this out. Certainly on X, you know, people can say anything they want. People saying, oh, you know, I didn't feel well.”

“The problem is no one's doing the work to figure that out. You painted this picture where not you, perhaps, but let's just say another physician has the awareness that BPC-157 might be useful to a patient of theirs that's dealing with a they had like an ACL tear.”

“Or even in glaucoma. I should mention that BPC-157, to my knowledge, hasn't been looked at extensively in terms of optic nerve repair, but it absolutely should be. If someone knows those papers, please put them in the comments. So I was intrigued.”

“When I hear about thymosin alpha, TB500, BPC, it occupies this kind of middle ground.”

“Wolverine stack, which someone online just made up. That's the Wolverine stack? It's those two? Yeah. TB500 and Thymosin Alpha? No, TB500 and BPC-157. And BPC-157. Yes. Now people will add on GHK copper and call it the glow stack. The glow stack. Yeah. Oh, interesting. Yeah. Someone has made it up.”

“Yes. I don't think anyone thinks it causes cancer. It's not mutagenic. This is the big debate when people are like, BPC causes cancer. There's no mutagenic effect from BPC. Is BPC like smoking a cigarette? Smoking a cigarette, you get carcinogenic damage to the lung tissue that causes a cancer later on. There's no direct mechanism that would link any of these peptides to a carcinogenic effect.”

“When it comes to the peptides coming back to category one. The first round is going to have these seven peptides. BPC, TB, etc. And the second round is going to look at GHK. I don't imagine that makes it. There's no good human data on that. But topically, there's great human data on like different aesthetic outcomes. Especially when coupled with red light therapy.”

“nomenclature to divide up what we've talked about today you know bpc 157 um you know peptides with and without known receptors the regenerative peptides as you've called them things like thymus and alpha tb500 which are immunogenic peptides i”

“potential can things like bpc 157 help and or hurt those circumstances given their potential role in angiogenesis and the other things you described no literature exists on either animal or human”

“Yeah, there were studies in Russia on TBI's when it comes to Cortexin and Cerebrolysin which would probably never be available in the United States so we'll skip those. There's no good data on BPC and TBIs they theoretically could be useful from an anti-stress perspective”

“The question that's going to happen. Is there's going to be a lot of these orally available peptides and they're going to be all over supplement websites. Like you'll, you'll find them with your magnesium and your creatine and then your Pinealon or your BPC-157. The question is, what is that gonna look like?”

“no discussion on the topic would be complete without that, the origin story, the proposed mechanisms, and the nature of the animal and human evidence that's often cited. We're going to talk about the role of patents and the incentives in drug development, and why some compounds do or don't advance through formal clinical pipelines.”

“melanitan 2, CJC 1295, and BPC 157. Why did we pick those four? They're incredibly popular. They're probably the ones I get asked about the most from patients, friends, anybody.”